rat SFRS2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Rat Srsf2.
shADV-290000
Ad-r-SFRS2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Rat Srsf2 (serine and arginine rich splicing factor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Sfrs2
Description (Vector)
Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.
Gene ID
494445
Gene Name (Vector)
serine and arginine rich splicing factor 2
Gene Symbol
Srsf2
ORF Size (aa)
666
RefSeq ID
NM_001009720
RefSeq Synonyms
NM_001009720, BC058508,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.