mouse CLK2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Clk2.
shADV-278418
Ad-m-CLK2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Clk2 (CDC-like kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AU041688
Description (Vector)
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Gene ID
12748
Gene Name (Vector)
CDC-like kinase 2
Gene Symbol
Clk2
ORF Size (aa)
1497
ORF Size (bp)
1497 bp
RefSeq ID
NM_007712
RefSeq Synonyms
NM_007712, NM_001163432, BC015080,
Species
mouse
UniGene ID
Mm.
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.