mouse USP8 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Usp8.
shADV-275758
Ad-m-USP8-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Usp8 (ubiquitin specific peptidase 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI574262; AW557536; mKIAA0055; Ubpy
Description (Vector)
Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.
Gene ID
84092
Gene Name (Vector)
ubiquitin specific peptidase 8
Gene Symbol
Usp8
ORF Size (aa)
3243
ORF Size (bp)
3243 bp
RefSeq ID
NM_019729
RefSeq Synonyms
NM_019729, NM_001252580, BC066126, BC061465, BC050947,
Species
mouse
UniGene ID
Mm.272629
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.