mouse USP2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Usp2.
shADV-275720
Ad-m-USP2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Usp2 (ubiquitin specific peptidase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
B930035K21Rik; Ubp41
Description (Vector)
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.
Gene ID
53376
Gene Name (Vector)
ubiquitin specific peptidase 2
Gene Symbol
Usp2
ORF Size (aa)
1860
ORF Size (bp)
1860 bp
RefSeq ID
NM_016808
RefSeq Synonyms
NM_198092, NM_198091, NM_016808, BC017517,
Species
mouse
UniGene ID
Mm.272770
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.