mouse UNC5B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Unc5b.
shADV-275637
Ad-m-UNC5B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Unc5b (unc-5 netrin receptor B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
6330415E02Rik; A630020F16; D10Bwg0792e; Unc5h2
Description (Vector)
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
Gene ID
107449
Gene Name (Vector)
unc-5 netrin receptor B
Gene Symbol
Unc5b
ORF Size (aa)
2805
ORF Size (bp)
2805 bp
RefSeq ID
NM_029770
RefSeq Synonyms
NM_029770, BC057560,
Species
mouse
UniGene ID
Mm.290433
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.