mouse UMOD shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Umod.
shADV-275624
Ad-m-UMOD-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Umod (uromodulin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
THP; Urehd1; urehr4
Description (Vector)
Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serves as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial|Function: Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.
Gene ID
22242
Gene Name (Vector)
uromodulin
Gene Symbol
Umod
ORF Size (aa)
1929
ORF Size (bp)
1929 bp
RefSeq ID
NM_009470
RefSeq Synonyms
NM_009470, NM_001278605, BC012973,
Species
mouse
UniGene ID
Mm.10826
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.