mouse ULK3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ulk3.
shADV-275621
Ad-m-ULK3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ulk3 (unc-51-like kinase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1200015E14Rik
Description (Vector)
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Gene ID
71742
Gene Name (Vector)
unc-51-like kinase 3
Gene Symbol
Ulk3
ORF Size (aa)
1419
ORF Size (bp)
1419 bp
RefSeq ID
NM_027895
RefSeq Synonyms
NM_027895, BC151153,
Species
mouse
UniGene ID
Mm.155877
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.