mouse ULK2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ulk2.
shADV-275619
Ad-m-ULK2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ulk2 (unc-51 like kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
A830085I22Rik; AU015340; mKIAA0623; Unc51.2
Description (Vector)
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
Gene ID
29869
Gene Name (Vector)
unc-51 like kinase 2
Gene Symbol
Ulk2
ORF Size (aa)
3114
ORF Size (bp)
3114 bp
RefSeq ID
NM_013881
RefSeq Synonyms
NM_013881, BC053029, BC046778,
Species
mouse
UniGene ID
Mm.162025
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.