mouse UBA52 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Uba52.
shADV-275438
Ad-m-UBA52-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Uba52 (ubiquitin A-52 residue ribosomal protein fusion product 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
D8Ertd21e; Gm1863; Rps27a; Ubb; Ubc
Description (Vector)
Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling|Function: Ribosomal protein L40 is a component of the 60S subunit of the ribosome.
Gene ID
22186
Gene Name (Vector)
ubiquitin A-52 residue ribosomal protein fusion product 1
Gene Symbol
Uba52
ORF Size (aa)
387
RefSeq ID
NM_019883
RefSeq Synonyms
NM_019883, BC087922, BC086924, BC080838, BC054413, BC014772,
Species
mouse
UniGene ID
Mm.297372
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.