mouse STK24 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Stk24.
shADV-273334
Ad-m-STK24-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Stk24 (serine/threonine kinase 24). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1810013H02Rik; C76483; MST-3; Mst3; STE20
Description (Vector)
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
Gene ID
223255
Gene Name (Vector)
serine/threonine kinase 24
Gene Symbol
Stk24
ORF Size (aa)
1296
ORF Size (bp)
1296 bp
RefSeq ID
NM_145465
RefSeq Synonyms
NM_145465, BC004650,
Species
mouse
UniGene ID
Mm.472866
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.