mouse SRGN shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Srgn.
shADV-273140
Ad-m-SRGN-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Srgn (serglycin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Prg; Prg1; Sgc
Description (Vector)
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
Gene ID
19073
Gene Name (Vector)
serglycin
Gene Symbol
Srgn
ORF Size (aa)
459
RefSeq ID
NM_011157
RefSeq Synonyms
NM_011157, BC037076,
Species
mouse
UniGene ID
Mm.338790
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.