mouse SMC1B shRNA silencing Adenovirus

Name 
Ad-m-SMC1B-shRNA
Cat No 
shADV-272626
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Smc1b.

shADV-272626
Ad-m-SMC1B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Smc1b (structural maintenance of chromosomes 1B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
SMC-1B; SMC1beta; Smc1l2
Description (Vector)
Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
Gene ID
140557
Gene Name (Vector)
structural maintenance of chromosomes 1B
Gene Symbol
Smc1b
ORF Size (aa)
3747
ORF Size (bp)
3747 bp
RefSeq ID
NM_080470
RefSeq Synonyms
NM_080470, BC129800,
Species
mouse
UniGene ID
Mm.182737

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.