mouse SMAD2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Smad2.
shADV-272599
Ad-m-SMAD2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Smad2 (SMAD family member 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
7120426M23Rik; Madh2; Madr2; mMad2; Smad-2
Description (Vector)
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Gene ID
17126
Gene Name (Vector)
SMAD family member 2
Gene Symbol
Smad2
ORF Size (aa)
1404
ORF Size (bp)
1404 bp
RefSeq ID
NM_010754
RefSeq Synonyms
NM_010754, NM_001311070, NM_001252481, BC089184, BC021342,
Species
mouse
UniGene ID
Mm.391091
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.