mouse SKP2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse SKP2.
shADV-272037
Ad-m-SKP2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse SKP2 (S-phase kinase-associated protein 2 (p45)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4930500A04Rik; FBXL1; FWD1; p45
Description (Vector)
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2.
Gene ID
27401
Gene Name (Vector)
S-phase kinase-associated protein 2 (p45)
Gene Symbol
SKP2
ORF Size (aa)
1275
ORF Size (bp)
1275 bp
RefSeq ID
NM_013787
RefSeq Synonyms
NM_145468, NM_013787, NM_001285980, BC092236,
Species
mouse
UniGene ID
Mm.35584
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.