mouse SHC1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Shc1.
shADV-271935
Ad-m-SHC1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Shc1 (src homology 2 domain-containing transforming protein C1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
p66; p66shc; Shc; ShcA
Description (Vector)
Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
Gene ID
20416
Gene Name (Vector)
src homology 2 domain-containing transforming protein C1
Gene Symbol
Shc1
ORF Size (aa)
1410
ORF Size (bp)
1410 bp
RefSeq ID
NM_011368
RefSeq Synonyms
NM_011368, NM_001113331, BC036172,
Species
mouse
UniGene ID
Mm.86595
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.