mouse SGMS1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Sgms1.
shADV-271857
Ad-m-SGMS1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Sgms1 (sphingomyelin synthase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
9530058O11Rik; AI841905; C80702; Mob; Sms1; Sor1; Tmem23
Description (Vector)
Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Required for cell growth.
Gene ID
208449
Gene Name (Vector)
sphingomyelin synthase 1
Gene Symbol
Sgms1
ORF Size (aa)
1260
ORF Size (bp)
1260 bp
RefSeq ID
NM_144792
RefSeq Synonyms
NM_144792, NM_001168526, NM_001168525, BC085298, BC019443,
Species
mouse
UniGene ID
Mm.329810
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.