mouse RPRD1B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Rprd1b.
shADV-271003
Ad-m-RPRD1B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Rprd1b (regulation of nuclear pre-mRNA domain containing 1B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610304G08Rik; 2810446G03Rik; Crept
Description (Vector)
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.
Gene ID
70470
Gene Name (Vector)
regulation of nuclear pre-mRNA domain containing 1B
Gene Symbol
Rprd1b
ORF Size (aa)
978
ORF Size (bp)
978 bp
RefSeq ID
NM_027434
RefSeq Synonyms
NM_027434, NM_001291136, NM_001291135, NM_001291134, BC054350, BC042447, BC028819,
Species
mouse
UniGene ID
Mm.290810
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.