mouse RNF144B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Rnf144b.
shADV-270697
Ad-m-RNF144B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Rnf144b (ring finger protein 144B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BC025007; E130105P19Rik; Ibrdc2; Pir2
Description (Vector)
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Gene ID
218215
Gene Name (Vector)
ring finger protein 144B
Gene Symbol
Rnf144b
ORF Size (aa)
465
RefSeq ID
NM_146042
RefSeq Synonyms
NM_146042, NM_001170643, BC025007,
Species
mouse
UniGene ID
Mm.461654
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.