mouse RHOA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Rhoa.
shADV-270528
Ad-m-RHOA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Rhoa (ras homolog family member A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Arha; Arha1; Arha2
Description (Vector)
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Gene ID
11848
Gene Name (Vector)
ras homolog family member A
Gene Symbol
Rhoa
ORF Size (aa)
582
RefSeq ID
NM_016802
RefSeq Synonyms
NM_016802, NM_001313962, NM_001313961, BC096423, BC068115,
Species
mouse
UniGene ID
Mm.471622
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.