mouse PTPRB shRNA silencing Adenovirus

Cat. No: shADV-269812

Availability: 5-8 weeks

Name: Ad-m-PTPRB-shRNA

This is an Adenovirus expressing shRNA for silencing of Mouse Ptprb.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Species: Mouse
Gene Symbol: Ptprb
Gene Name: protein tyrosine phosphatase, receptor type, B
Gene ID: 19263
Gene Synonyms: 3230402H02Rik; C130094E24; Ptpz; Rptpb; VE-PTP; Veptp
ORF Size: 5997 bp
RefSeq#: NM_029928
Gene Description: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
UniGene ID: Mm.37213