mouse PSMA7 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Psma7.
shADV-269626
Ad-m-PSMA7-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Psma7 (proteasome (prosome, macropain) subunit, alpha type 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C6-I
Description (Vector)
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.
Gene ID
26444
Gene Name (Vector)
proteasome (prosome, macropain) subunit, alpha type 7
Gene Symbol
Psma7
ORF Size (aa)
747
RefSeq ID
NM_011969
RefSeq Synonyms
NM_011969, NM_001289476, BC008222,
Species
mouse
UniGene ID
Mm.21728
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.