mouse PLK2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Plk2.
shADV-268880
Ad-m-PLK2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Plk2 (polo-like kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Snk
Description (Vector)
Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
Gene ID
20620
Gene Name (Vector)
polo-like kinase 2
Gene Symbol
Plk2
ORF Size (aa)
2049
ORF Size (bp)
2049 bp
RefSeq ID
NM_152804
RefSeq Synonyms
NM_152804, BC034513,
Species
mouse
UniGene ID
Mm.380
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.