mouse PLEKHG6 shRNA silencing Adenovirus

Name
Ad-m-PLEKHG6-shRNA

Cat No
shADV-268868

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Mouse Plekhg6.

shADV-268868

Ad-m-PLEKHG6-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Plekhg6 (pleckstrin homology domain containing, family G (with RhoGef domain) member 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

BC026778; Gm155

Description (Vector)

Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

Gene ID

213522

Gene Name (Vector)

pleckstrin homology domain containing, family G (with RhoGef domain) member 6

Gene Symbol

Plekhg6

ORF Size (aa)

2364

ORF Size (bp)

2364 bp

RefSeq ID

NM_198604

RefSeq Synonyms

NM_198604, BC026778,

Species

mouse

UniGene ID

Mm.333396

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.