mouse PLAG1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Plag1.
shADV-268796
Ad-m-PLAG1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Plag1 (pleiomorphic adenoma gene 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.
Gene ID
56711
Gene Name (Vector)
pleiomorphic adenoma gene 1
Gene Symbol
Plag1
ORF Size (aa)
1500
ORF Size (bp)
1500 bp
RefSeq ID
NM_019969
RefSeq Synonyms
NM_019969, BC139285, BC139283,
Species
mouse
UniGene ID
Mm.331467
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.