mouse PKN1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Pkn1.
shADV-268739
Ad-m-PKN1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Pkn1 (protein kinase N1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DBK; F730027O18Rik; PAK1; Pkn; PRK1; Prkcl1; Stk3
Description (Vector)
PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.
Gene ID
320795
Gene Name (Vector)
protein kinase N1
Gene Symbol
Pkn1
ORF Size (aa)
2841
ORF Size (bp)
2841 bp
RefSeq ID
NM_177262
RefSeq Synonyms
NM_177262, NM_001199593, BC052923,
Species
mouse
UniGene ID
Mm.213000
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.