mouse PARP1 shRNA silencing Adenovirus

Name 
Ad-m-PARP1-shRNA
Cat No 
shADV-268074
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Parp1.

shADV-268074
Ad-m-PARP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Parp1 (poly (ADP-ribose) polymerase family, member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
5830444G22Rik; Adprp; Adprt1; AI893648; ARTD1; C80510; PARP; parp-1; PPOL; sPARP-1
Description (Vector)
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Gene ID
11545
Gene Name (Vector)
poly (ADP-ribose) polymerase family, member 1
Gene Symbol
Parp1
ORF Size (aa)
3045
ORF Size (bp)
3045 bp
RefSeq ID
NM_007415
RefSeq Synonyms
NM_007415, BC012041,
Species
mouse
UniGene ID
Mm.277779

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.