mouse NFKBIZ shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Nfkbiz.
shADV-265731
Ad-m-NFKBIZ-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Nfkbiz (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AA408868; INAP; Mail
Description (Vector)
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).
Gene ID
80859
Gene Name (Vector)
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
Gene Symbol
Nfkbiz
ORF Size (aa)
2187
ORF Size (bp)
2187 bp
RefSeq ID
NM_030612
RefSeq Synonyms
NM_030612, NM_001159395, NM_001159394, BC058188,
Species
mouse
UniGene ID
Mm.247272
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.