mouse NAE1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Nae1.
shADV-265405
Ad-m-NAE1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Nae1 (NEDD8 activating enzyme E1 subunit 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
59kDa; Appbp1
Description (Vector)
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Gene ID
234664
Gene Name (Vector)
NEDD8 activating enzyme E1 subunit 1
Gene Symbol
Nae1
ORF Size (aa)
1605
ORF Size (bp)
1605 bp
RefSeq ID
NM_144931
RefSeq Synonyms
NM_144931, BC027124, BC023897, BC023680, BC021510, BC019163,
Species
mouse
UniGene ID
Mm.237670
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.