mouse LRP5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Lrp5.
shADV-263816
Ad-m-LRP5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Lrp5 (low density lipoprotein receptor-related protein 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG
Description (Vector)
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
Gene ID
16973
Gene Name (Vector)
low density lipoprotein receptor-related protein 5
Gene Symbol
Lrp5
ORF Size (aa)
4845
ORF Size (bp)
4845 bp
RefSeq ID
NM_008513
RefSeq Synonyms
NM_008513, BC011374,
Species
mouse
UniGene ID
Mm.274581
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.