mouse KRT17 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Krt17.
shADV-263076
Ad-m-KRT17-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Krt17 (keratin 17). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
K17; Krt1-17
Description (Vector)
KRT17 may play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair (By similarity).
Gene ID
16667
Gene Name (Vector)
keratin 17
Gene Symbol
Krt17
ORF Size (aa)
1302
ORF Size (bp)
1302 bp
RefSeq ID
NM_010663
RefSeq Synonyms
NM_010663, BC132456, BC132454,
Species
mouse
UniGene ID
Mm.14046
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.