mouse JUB shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ajuba.
shADV-262546
Ad-m-JUB-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ajuba (ajuba LIM protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Jub
Description (Vector)
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.
Gene ID
16475
Gene Name (Vector)
ajuba LIM protein
Gene Symbol
Ajuba
ORF Size (aa)
1644
ORF Size (bp)
1644 bp
RefSeq ID
NM_010590
RefSeq Synonyms
NM_010590, BC011035,
Species
mouse
UniGene ID
Mm.100253
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.