mouse HIPK3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Hipk3.
shADV-261309
Ad-m-HIPK3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Hipk3 (homeodomain interacting protein kinase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DYRK6; FIST3; mir-1902; PKY
Description (Vector)
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
Gene ID
15259
Gene Name (Vector)
homeodomain interacting protein kinase 3
Gene Symbol
Hipk3
ORF Size (aa)
3576
ORF Size (bp)
3576 bp
RefSeq ID
NM_010434
RefSeq Synonyms
NM_010434, NM_001145824, BC131664,
Species
mouse
UniGene ID
Mm.389331
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.