mouse HIF3A shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Hif3a.
shADV-261291
Ad-m-HIF3A-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Hif3a (hypoxia inducible factor 3, alpha subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
bHLHe17; Ipas; MOP7; NEPAS
Description (Vector)
Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea (By similarity).
Gene ID
53417
Gene Name (Vector)
hypoxia inducible factor 3, alpha subunit
Gene Symbol
Hif3a
ORF Size (aa)
1989
ORF Size (bp)
1989 bp
RefSeq ID
NM_016868
RefSeq Synonyms
NM_016868, NM_001162950, BC120587,
Species
mouse
UniGene ID
Mm.135110
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.