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mouse HAVCR2 shRNA silencing Adenovirus

Name 
Ad-m-HAVCR2-shRNA
Cat No 
shADV-261129
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Havcr2.

shADV-261129
Ad-m-HAVCR2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Havcr2 (hepatitis A virus cellular receptor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD366; HAVcr-2; hepatitis A virus cellular receptor 2 homolog; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; Timd3; TIMD-3
Description (eCommerce)
TIM3 (HAVCR2) is a cell surface receptor implicated in modulating innate and adaptive immune responses. It is generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. TIM3 regulates macrophage activation, inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses, and promotes immunological tolerance. In CD8+ cells TIM3 attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion.  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8TDQ0].
Description (Vector)
Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.
Gene ID
171285
Gene Name (eCommerce)
hepatitis A virus cellular receptor 2
Gene Name (Vector)
hepatitis A virus cellular receptor 2
Gene Symbol
Havcr2
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
846
Protein Name (eCommerce)
Hepatitis A virus cellular receptor 2 homolog
RefSeq ID
NM_134250
RefSeq Synonyms
NM_134250, BC106852, BC106851,
Research Areas
Immune Cells and Tumor Markers,Immune-checkpoints,Immunology,Immuno-Oncology,Signal Transduction,T-cell markers
Research Areas (Faceted)
immuno_oncology,immunology,signal_transduction
Species
mouse
Target Sentence
TIM3 (HAVCR2) is a cell surface receptor implicated in modulating innate and adaptive immune responses. It is generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. TIM3 regulates macrophage activation, inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses, and promotes immunological tolerance. In CD8+ cells TIM3 attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion.  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8TDQ0].
UniGene ID
Mm.72168
UniProt ID (eCommerce)
Q8VIM0

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.