mouse EXOSC10 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Exosc10.
shADV-258789
Ad-m-EXOSC10-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Exosc10 (exosome component 10). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
p2; p3; p4; PM-Scl; PM/Scl-100; Pmscl2; RRP6
Description (Vector)
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.
Gene ID
50912
Gene Name (Vector)
exosome component 10
Gene Symbol
Exosc10
ORF Size (aa)
2664
ORF Size (bp)
2664 bp
RefSeq ID
NM_016699
RefSeq Synonyms
NM_016699, BC027840, BC027326,
Species
mouse
UniGene ID
Mm.266635
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.