mouse ERBB2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Erbb2.
shADV-258621
Ad-m-ERBB2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Erbb2 (erb-b2 receptor tyrosine kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
c-erbB2; c-neu; Erbb-2; HER-2; HER2; l11Jus8; mKIAA3023; Neu
Description (Vector)
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization|Function: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Gene ID
13866
Gene Name (Vector)
erb-b2 receptor tyrosine kinase 2
Gene Symbol
Erbb2
ORF Size (aa)
2136
ORF Size (bp)
2136 bp
RefSeq ID
NM_001003817
RefSeq Synonyms
NM_001003817, BC053078, BC046811,
Species
mouse
UniGene ID
Mm.406337
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.