mouse EFCAB4B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Cracr2a.
shADV-257795
Ad-m-EFCAB4B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Cracr2a (calcium release activated channel regulator 2A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Efcab4b; Gm1073; Gm462
Description (Vector)
Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Gene ID
381812
Gene Name (Vector)
calcium release activated channel regulator 2A
Gene Symbol
Cracr2a
ORF Size (aa)
933
ORF Size (bp)
933 bp
RefSeq ID
NM_001033464
RefSeq Synonyms
NM_001033464, BC150869,
Species
mouse
UniGene ID
Mm.296093
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.