mouse EBI3 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-257712
Availability:
5-8 weeks
Name:
Ad-m-EBI3-shRNA
This is an Adenovirus expressing shRNA for silencing of Mouse Ebi3.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Ebi3
- Gene Name
- Epstein-Barr virus induced gene 3
- Gene ID
- 50498
- Gene Synonyms
- EBI-3; IL-27
- ORF Size
- 687 bp
- RefSeq#
- NM_015766
- Gene Description
- Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
- UniGene ID
- Mm.256798
Related Products
Product | Cat No. |
---|---|
AAV-h-EBI3 | AAV-207516 |
AAV-m-EBI3 | AAV-257712 |
Ad-h-EBI3 | ADV-207516 |
Ad-m-EBI3 | ADV-257712 |
AAV-h-EBI3-shRNA | shAAV-207516 |
AAV-m-EBI3-shRNA | shAAV-257712 |
Ad-h-EBI3-shRNA | shADV-207516 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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