mouse CYLD shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse CYLD.
shADV-256457
Ad-m-CYLD-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse CYLD (CYLD lysine 63 deubiquitinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2010013M14Rik; 2900009M21Rik; C130039D01Rik; CDMT; CYLD1; EAC; mKIAA0849
Description (Vector)
Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation. Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity).
Gene ID
74256
Gene Name (Vector)
CYLD lysine 63 deubiquitinase
Gene Symbol
CYLD
ORF Size (aa)
2859
ORF Size (bp)
2859 bp
RefSeq ID
NM_173369
RefSeq Synonyms
NM_173369, NM_001276279, NM_001128171, NM_001128170, NM_001128169, BC042438,
Species
mouse
UniGene ID
Mm.24282
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.