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mouse CLSPN shRNA silencing Adenovirus

Name 
Ad-m-CLSPN-shRNA
Cat No 
shADV-255699
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Clspn.

shADV-255699
Ad-m-CLSPN-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Clspn (claspin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
B130025E01; C85083; E130314M08Rik
Description (Vector)
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.
Gene ID
269582
Gene Name (Vector)
claspin
Gene Symbol
Clspn
ORF Size (aa)
3948
ORF Size (bp)
3948 bp
RefSeq ID
NM_175554
RefSeq Synonyms
NM_175554, BC050848,
Species
mouse
UniGene ID
Mm.243962

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.