mouse CHMP5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Chmp5.
shADV-255420
Ad-m-CHMP5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Chmp5 (charged multivesicular body protein 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2210412K09Rik; AW545668
Description (Vector)
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.
Gene ID
76959
Gene Name (Vector)
charged multivesicular body protein 5
Gene Symbol
Chmp5
ORF Size (aa)
660
RefSeq ID
NM_029814
RefSeq Synonyms
NM_029814, BC006947,
Species
mouse
UniGene ID
Mm.212763
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.