mouse CBL shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Cbl.
shADV-254602
Ad-m-CBL-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Cbl (Casitas B-lineage lymphoma). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4732447J05Rik; c-Cbl; Cbl-2
Description (Vector)
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The Tyr-731 phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.
Gene ID
12402
Gene Name (Vector)
Casitas B-lineage lymphoma
Gene Symbol
Cbl
ORF Size (aa)
2742
ORF Size (bp)
2742 bp
RefSeq ID
NM_007619
RefSeq Synonyms
NM_007619, BC125285,
Species
mouse
UniGene ID
Mm.266871
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.