mouse CACNA1S shRNA silencing Adenovirus

Name 
Ad-m-CACNA1S-shRNA
Cat No 
shADV-254368
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Cacna1s.

shADV-254368
Ad-m-CACNA1S-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Cacna1s (calcium channel, voltage-dependent, L type, alpha 1S subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AW493108; Cav1.1; Cchl1a3; fmd; mdg; sj
Description (Vector)
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
Gene ID
12292
Gene Name (Vector)
calcium channel, voltage-dependent, L type, alpha 1S subunit
Gene Symbol
Cacna1s
ORF Size (aa)
5559
ORF Size (bp)
5559 bp
RefSeq ID
NM_001081023
RefSeq Synonyms
NM_014193, NM_001081023, BC172641,
Species
mouse
UniGene ID
Mm.4418

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.