mouse BIRC3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Birc3.
shADV-253989
Ad-m-BIRC3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Birc3 (baculoviral IAP repeat-containing 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Api1; Api2; AW107670; Birc2; C-IAP2; cIAP-1; cIAP-2; cIAP1; cIAP2; HIAP2; IAP1; IAP2; MIAP1; MIAP2; MIHB; MIHC; RNF49
Description (Vector)
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Gene ID
11796
Gene Name (Vector)
baculoviral IAP repeat-containing 3
Gene Symbol
Birc3
ORF Size (aa)
1131
ORF Size (bp)
1131 bp
RefSeq ID
NM_007464
RefSeq Synonyms
NM_007464, BC011338,
Species
mouse
UniGene ID
Mm.2026
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.