mouse SRPK2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Srpk2.
shADV-253411
Ad-m-SRPK2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Srpk2 (serine/arginine-rich protein specific kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW226533; AW492537; AW547358; mSRPK2; Wbp6
Description (Vector)
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in splicesomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.
Gene ID
20817
Gene Name (Vector)
serine/arginine-rich protein specific kinase 2
Gene Symbol
Srpk2
ORF Size (aa)
2049
ORF Size (bp)
2049 bp
RefSeq ID
NM_009274
RefSeq Synonyms
NM_009274, BC020178,
Species
mouse
UniGene ID
Mm.288728
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.