mouse PDCD6IP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Pdcd6ip.
shADV-252301
Ad-m-PDCD6IP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Pdcd6ip (programmed cell death 6 interacting protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI480591; Aip1; Alix; AW544830; C76364; Eig2; mKIAA1375
Description (Vector)
Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.
Gene ID
18571
Gene Name (Vector)
programmed cell death 6 interacting protein
Gene Symbol
Pdcd6ip
ORF Size (aa)
2610
ORF Size (bp)
2610 bp
RefSeq ID
NM_011052
RefSeq Synonyms
NM_011052, NM_001164678, NM_001164677, BC051123, BC026823,
Species
mouse
UniGene ID
Mm.29816
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.