mouse 4933407H18RIK shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Uvssa.
shADV-251272
Ad-m-4933407H18RIK-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Uvssa (UV stimulated scaffold protein A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4933407H18Rik; D330017J19Rik; Kiaa1530; mKIAA1530
Description (Vector)
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.
Gene ID
71101
Gene Name (Vector)
UV stimulated scaffold protein A
Gene Symbol
Uvssa
ORF Size (aa)
2154
ORF Size (bp)
2154 bp
RefSeq ID
NM_001081101
RefSeq Synonyms
NM_001081101, BC144920, BC137803,
Species
mouse
UniGene ID
Mm.132178
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.