mouse ABI1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Abi1.
shADV-250584
Ad-m-ABI1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Abi1 (abl-interactor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
abi-1; E3B1; NAP1; Ssh3bp1
Description (Vector)
ABI1 may act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level (By similarity).
Gene ID
11308
Gene Name (Vector)
abl-interactor 1
Gene Symbol
Abi1
ORF Size (aa)
1431
ORF Size (bp)
1431 bp
RefSeq ID
NM_007380
RefSeq Synonyms
NM_145994, NM_007380, NM_001331045, NM_001331044, NM_001331043, NM_001077193, NM_001077192, NM_001077190, BC079642, BC004657,
Species
mouse
UniGene ID
Mm.205647
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.