mouse 2010106G01RIK shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Sppl2a.
shADV-250549
Ad-m-2010106G01RIK-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Sppl2a (signal peptide peptidase like 2A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2010106G01Rik; C130089K23Rik
Description (Vector)
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity.
Gene ID
66552
Gene Name (Vector)
signal peptide peptidase like 2A
Gene Symbol
Sppl2a
ORF Size (aa)
1002
ORF Size (bp)
1002 bp
RefSeq ID
NM_023220
RefSeq Synonyms
NM_023220, BC026578,
Species
mouse
UniGene ID
Mm.473757
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.