human ATP2B2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human ATP2B2.
shADV-233936
Ad-h-ATP2B2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PMCA2; PMCA2a; PMCA2i
Description (Vector)
ATP2B2 belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
491
Gene Name (Vector)
ATPase plasma membrane Ca2+ transporting 2
Gene Symbol
ATP2B2
HGNC ID
HGNC:815
ORF Size (aa)
3732
ORF Size (bp)
3732 bp
RefSeq ID
NM_001001331
RefSeq Synonyms
NM_001683, NM_001330611, NM_001001331, BC128575,
Species
human
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.